Gene Information

Name : cpa (PAB0593)
Accession : NP_126565.1
Strain : Pyrococcus abyssi GE5
Genome accession: NC_000868
Putative virulence/resistance : Unknown
Product : carbamate kinase-like carbamoyl phosphate synthetase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0549
EC number : -
Position : 849737 - 850681 bp
Length : 945 bp
Strand : +
Note : this enzyme from Pyrococcus has carbamoyl phosphate synthetase activity even though the enzyme shows sequence and structural similarity to carbamate kinase; this enzyme using carbate and ATP to synthesize carbamoyl phosphate which may be a favorable react

DNA sequence :
ATGCCGGAGAGAGTCGTCATAGCCCTCGGAGGAAACGCCCTTCAGCAGAGGGGTCAAAAGGGAACGTACGAGGAGATGAT
GGAGAACGTTAAGAAAACTGCAAAGCAGATAGCTGAAATTATCGCGAGGGGTTACGAAGTGGTTATAACCCACGGAAATG
GCCCTCAGGTAGGGACGATCCTCCTTCACATGGACGCTGGCCAATCACTTCACGGAATTCCAGCTCAGCCCATGGACGTT
GCTGGGGCAATGAGCCAGGGATGGATAGGTTACATGATACAGCAGGCACTGAGGAACGAGCTTAGGAAGAGGGGGATAGA
GAGGGAGGTAGTTACGATAGTTACCCAGACAATAGTAGATAAGGACGATCCTGCCTTCGAGAACCCAACTAAACCAGTTG
GCCCGTTCTACGACGAGGAAACTGCAAAGAAACTAGCTAAGGAAAAGGGATGGGTAGTGAAGGAAGACGCTGGAAGGGGA
TGGAGGAGGGTAGTTCCAAGCCCAGATCCAAAGAGGCACGTAGAGGCTGAGACCATAAAGAAGTTAGTTGAGGATGGCGT
TATAGTTATAGCGAGCGGCGGGGGAGGAGTGCCGGTAATAGAGGAGGATGGAGAGATAAAAGGGGTCGAAGCGGTAATAG
ACAAGGATCTAGCGGGAGAGAGGTTAGCTGAGGAGGTTAACGCTGACATACTGATGATCTTAACGGATGTAAACGGGGCA
GCACTCTACTACGGAACCGAGAAGGAGACCTGGCTTAGAGAAGTTAAGGTGGACGAGATGGAGAGGTACTATCAAGAAGG
GCACTTCAAGGCCGGAAGCATGGGGCCAAAGGTTTTAGCTGCTATAAGGTTCGTGAAGAACGGAGGAAAGAGGGCAATAA
TTGCTCACCTTGAGAAAGCTGTTGAAGCCCTGGAAGGAAAGACCGGGACACAGGTTATTCCCTGA

Protein sequence :
MPERVVIALGGNALQQRGQKGTYEEMMENVKKTAKQIAEIIARGYEVVITHGNGPQVGTILLHMDAGQSLHGIPAQPMDV
AGAMSQGWIGYMIQQALRNELRKRGIEREVVTIVTQTIVDKDDPAFENPTKPVGPFYDEETAKKLAKEKGWVVKEDAGRG
WRRVVPSPDPKRHVEAETIKKLVEDGVIVIASGGGGVPVIEEDGEIKGVEAVIDKDLAGERLAEEVNADILMILTDVNGA
ALYYGTEKETWLREVKVDEMERYYQEGHFKAGSMGPKVLAAIRFVKNGGKRAIIAHLEKAVEALEGKTGTQVIP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0102 NP_763657.1 carbamate kinase Not tested SCCpbp4 Protein 2e-53 48
arcC1 YP_186045.1 carbamate kinase Not tested vSa¥ã Protein 5e-59 46
MW1051 NP_645868.1 carbamate kinase Not tested vSa¥ã Protein 5e-59 46
SAV1170 NP_371694.1 carbamate kinase Not tested vSa¥ã Protein 5e-59 46
SA1013 NP_374286.1 carbamate kinase Not tested vSa¥ã Protein 5e-59 46
arcC YP_493761.1 carbamate kinase Not tested vSa¥ã Protein 5e-59 46
SAKOR_01091 YP_008491279.1 Carbamate kinase Not tested vSa¥ã Protein 3e-59 46
APECO1_2636 YP_859422.2 carbamate kinase Not tested Not named Protein 9e-50 45