Gene Information

Name : PAB1441 (PAB1441)
Accession : NP_127086.2
Strain : Pyrococcus abyssi GE5
Genome accession: NC_000868
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1364333 - 1365760 bp
Length : 1428 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence : 
ATGAGGCTTCCTGATCACAAGACAAAGATAGTTGCAACAATAGGGCCCGCCACAAGCTCTAGGAATATGATAAAGAAGCT
AATAGAAAACGGTGTGAGCGTTGTGAGGCTCAACTTCTCTCACGGTAGCTTTGAGGAGCATGCAAAGGTCATAGAGAAAG
TCAGGGATATATCACAAAAGCTTGACAGAAGGGTTGCAATATTGGCCGACCTCCCAGGATTGAAGATTAGAGTGGGCGAG
ATAAAGGGAGGGTACGTAGAGCTTAAGAGAGGTGAGAAGGTAGTTTTGACTACGAGAGATGTTGTTGGGGATGAAACTAC
GATTCCCGTAGAGTACAAGGACTTCCCAAGATTAGTCTCCAAGGGCGACGTCATATACCTAAGTGACGGTTACATCGTTC
TTAGGGTTGAAGAGGTAAGGGGTCAAGACGTTGAGGCAGTTGTCGTCTCTGGTGGAAAACTGTTCTCAAGAAAGGGAATA
AACATTCCAAAGGCCTACCTACCAGTGGAGGCAGTAACTCCCAGGGACATGGAGATAATAAAGTTCGCCATCGAGCAGGG
AGTTGATGCAATAGGCTTAAGCTTTGTTGGAAGCGTTTATGACGTTCTCAAGGTTAAAAGTTTCCTCGAGAAGAATGATG
CCGAGGACGTCTTCGTTATTTCAAAGATAGAAAGACCGGACGCAGTCAGGAACTTCGATGAAATCCTGAAGGCTTCAGAT
GGCATCATGATAGCTAGAGGTGATCTTGGGGTTGAGATGCCGATAGAAAGATTGCCAATACTTCAGAAGGAGCTTATAAG
AAAGGCAAACACGGAGGGTAAGCCAGTAATAACAGCTACTCAGATGTTAGTTTCAATGACGGCCGAAAAGGTTCCAACCA
GAGCTGAAGTTACGGACGTTGCCAACGCGATACTTGACGGAACAGACGCGGTCATGCTCTCTGAGGAGACCGCGATTGGA
AAATTCCCAATCGATGCCGTCAAGATGATGGCAAAGATAGCCAAGGTCACCGAGGAGTACAGGGAGAGCTTTGGAATGTC
GAGGCTCAGGGAACTCGTGGAGGATGGGACAAGGGGGACAATAAAGGAGGCAATAGCGAGAAGCATAATAGATGCGCTCT
GCACCCTAAACATAAAGTACATACTAACCCCCACTAGAACGGGCAGGACGGCAAGGCTCATCTCGAGGTTTAAGCCAAAG
CAGTGGATATTTGGGTTCTCCACTAACGAAAGGGTTTGCAACAACTTGATGTTCAGCTATGGAGTTTATGCGTTCTGTCT
CGAGGAGGGCTTCGATGAGAGGGACATAATAAGGCTAATTAAGGGACTTGGACTGGTTGAGAGTGACGACATAGTGCTGA
TGACCGAGGGTAAGCCAATAGAGAAGACCATGGGAACGAACTCCATCAAGATATTCCAGATAGCGTGA

Protein sequence : 
MRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGE
IKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGI
NIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD
GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIG
KFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPK
QWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 3e-50 44
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 1e-66 41
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-66 41
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-66 41
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 3e-66 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
PAB1441 NP_127086.2 pyruvate kinase VFG0479 Protein 4e-67 41