Gene Information

Name : serS (PAB0881)
Accession : NP_127011.1
Strain : Pyrococcus abyssi GE5
Genome accession: NC_000868
Putative virulence/resistance : Unknown
Product : seryl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0172
EC number : 6.1.1.11
Position : 1290539 - 1291906 bp
Length : 1368 bp
Strand : +
Note : catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
ATGCTGGACATAAAGCTCATACGTGAAAATCCCGAGCTCGTGAAGAACGATCTAAAAAAGAGGGGAGAACTTGAAAAGAT
AAAGTGGATAGACGAGATTCTAAAGTTGGACGCTGAGTGGAGGGCCAAGCTAAAGGAAATAAACAAACTCAGGCATGAGA
GGAATAAAATAGCCATAGAAATAGGAAAGAGGAGAAAGAAAGGAGAGCCAGTCGAAGAGCTTCTAGCTAAGAGCAAAGAG
ATAGTGAAAAGGATAGAAAGTCTGGAAAAGGAAGTTGAAGAGCTCAAGAAGAAGATTGACTATTACTTATGGAGGCTTCC
CAACATAACACATCCAAGCGTTCCCATAGGAGAAAGCGAAGAGGATAACGTCCCAATTAGATTCTGGGGGAAAGCTAGGG
TCTGGGAAGGTCACCTAGAGAGATTCCTGGAGCAGAGCCAGGGGAAAATGGAGTACGAGGTTCTCGAGTGGAGGCCGAAG
TTGCACGTTGACCTGCTCGAAATCCTAGGAGGAGCGGACTTTGCAAGGGCAGCCAAGGTTAGCGGCTCGAGGTTCTACTA
CCTCCTAAACGAGATAGTTATACTGGACTTAGCGTTAATTAGGTTCGCCCTCGATGAGCTCATAAAGAAGGGCTTCACTC
CAGTAATCCCACCTTACATGGTTAGAAGATTCGTGGAGGAGGGCTCAACCACCTTCGAGGATTTCGAGGATGTCATATAC
AAGGTTGAAGGTGAGGACCTATACTTAATCCCGACCGCTGAGCATCCTTTAGCTGGAATGCACGCAAATGAGATCTTAGA
TGGAAAGGATTTACCGCTCCTCTACGTTGGAATATCGCCTTGCTTCAGGAAAGAGGCGGGAACTGCAGGAAAGGATACCA
AGGGAATATTCAGGGTTCACCAATTCCACAAGGTTGAGCAGTTCGTGTACTCTAGGCCTGAGGAGAGCTGGGAGTGGCAC
GAGAGGATAATAAGGAACGCCGAGGAACTCTTCCAGAAGCTCGAGATACCGTATAGGGTAGTGAACATATGCACTGGAGA
CCTTGGCTACGTGGCGGCTAAGAAGTACGATATAGAAGCTTGGATGCCTGGTCAAGGAAGATTTAGGGAAGTAGTTTCGG
CAAGCAACTGTACCGATTGGCAAGCTAGAAGGCTCAACATAAGATTTAGGGATAGAACAGATGAAAAGCCACGCTACGTT
CACACCTTAAATTCAACGGCCATAGCAACTTCTAGAGCGATAGTTGCGATACTTGAGAACCATCAAGAGGAAGATGGAAC
CGTGAAGATTCCGAAGGTTCTCTGGAAGTACACCGGCTTCAAGGAAATAGTTCCCGTAGAGAAGAAGGAGAGGTGTTGCT
CAAGTTGA

Protein sequence :
MLDIKLIRENPELVKNDLKKRGELEKIKWIDEILKLDAEWRAKLKEINKLRHERNKIAIEIGKRRKKGEPVEELLAKSKE
IVKRIESLEKEVEELKKKIDYYLWRLPNITHPSVPIGESEEDNVPIRFWGKARVWEGHLERFLEQSQGKMEYEVLEWRPK
LHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDELIKKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIY
KVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVGISPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWH
ERIIRNAEELFQKLEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYV
HTLNSTAIATSRAIVAILENHQEEDGTVKIPKVLWKYTGFKEIVPVEKKERCCSS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
serS YP_003446791.1 seryl-tRNA synthetase Not tested The aminoglycoside resistance gene cluster Protein 7e-72 41